Ben Affleck and Matt Damon
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They have known each other since childhood and rose to fame after winning Oscars for Good Will Hunting. They both still work together and can be seen on the TV show Project Greenlight which discovers rising filmmakers.
Jennifer Aniston and Courtney Cox
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After being cast as roommates in Friends, these girls became BFFs. Well, their work in Friends series does not require any introduction, and neither does their friendship.